Research Group Metabolic Interactions - Manuel Liebeke, PhD
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ORCID
GoogleScholar

submitted/under preparation

preprints

Sogin, E., Puskas, E.. Dubilier, N., Liebeke, M.
„Marine metabolomics: Measurement of metabolites in seawater by gas-chromatography mass spectrometry “
Gruber-Vodicka, H., Leisch, N., Kleiner, M., Liebeke, M., Hinzke, T., McFall Nigh, M., Hadfield, M., Dubilier, N.
„The Trichoplax microbiome: the simplest animal lives in an intimate symbiosis with two intracellular bacteria“
Geier, B. Sogin, M., Michellod, D., Janda, M., Kompauer, M., Spengler, B., Dubilier, N., Liebeke, M.
„Spatial metabolomics of in situ, host-microbe interactions “

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2019

[52] Liebeke, M., Puskas, E.
Metabolites 9 (4), 68; 2019
“Drying enhances signal intensity for global GC-MS metabolomics”
[51] Jäckle, O., Seah,B., Tietjen, M., Leisch, N:, Liebeke, M., Kleiner, M., Berg, J., Gruber-Vodicka, HR.
PNAS
„Chemosynthetic symbiont with a drastically reduced genome serves as primary energy storage in the marine flatworm Paracatenula”
[50] Berg, J., Pjevac, P. Sommer, T., Buckner, C., Philippi, M., Hach, P., Liebeke, M., Holtappels, M., Danza, F., Tonolla, M., Sengupta, A., Schubert, CJ., Milucka, J., Kuypers, MMM.
Environmental Microbiology
“Dark aerobic sulfide oxidation by anoxygenic phototrophs in anoxic waters”
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2018

[49] Puentes, E., Liebeke, M., Markert, S., Harder, J.
Journal of Biological Chemistry 293, 9520-9529.
„Limonene dehydrogenase hydroxylates the allylic methyl group of cyclic monoterpenes in the anaerobic terpene degradation by Castellaniella defragrans”
[48] Puentes-Cala E., Liebeke, M.; Markert, S.; Harder, J.
Metabolites 2018, 8(1), 12; doi:10.3390/metabo8010012
"Anaerobic Degradation of Bicyclic Monoterpenes in Castellaniella defragrans"
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2017

[47] Urbaniak, T.; Soto, M.; Liebeke, M.; Koschek, K.
The Journal of Organic Chemistry 82 (8), 4050-4055
"Insight into the Mechanism of Reversible Ring-Opening of 1, 3-Benzoxazine with Thiols"
[46] Rochfort, S.; Bailey-Wyatt, AM; Liebeke, M.; Southam, A.; Viant, M.; Bundy, JG
European Journal of Soil Biology 78, 17-19
"Aromatic metabolites from the coelomic fluid of Eisenia earthworm
species"
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2016

[45] Spurgeon, DJ.; Liebeke, M.; Anderson, C.; Kille, P.; Lawlor, A.; Bundy, JG.;  Lahive, E.
Applied Soil Ecology 108, 8-15
"Ecological drivers influence the distributions of two cryptic
lineages in an earthworm morphospecies"
[44] Hao,J., Liebeke, M., Sommer, U., Viant, M.,Bundy, JG., Ebbels T.
Analytical Chemistry
"Statistical correlations between NMR spectroscopy and direct infusion FT-ICR mass spectrometry aid annotation of unknowns in metabolomics"

[43] Schimak, MP., Kleiner, M., Wetzel, S., Liebeke, M., Dubilier, N., Fuchs, B.
Applied and Environmental Microbiology
16;82(1):62-70
"
MiL-FISH: Multi-labelled oligonucleotides for fluorescence in situ hybridisation improve visualization of bacterial cells"
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2015

[42] Liebeke, M., Strittmatter, N., Fearn, S., McPhail, D., Wallis, D., Palchykov, V., Robertson, J., Lahive, E., Spurgeon, D., L Morgen, J., Kille, P., Fuchser, J., Takats, Z., Bundy, JG.
Nature Communications
6, doi:10.1038/ncomms8869
"Unique metabolites protect earthworms against plant polyphenols"

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2014


[41] Liebeke, M., Bruford, MW., Donelly, RK., Ebbels, TMD., Hao, J., Kille, P., Lahive, E., Madison, R., Morgan, AJ., Pinto-Juma, GA., Spurgeon, DJ., Svendson, C., Bundy, JG.
Biology Letters 10 (9) 20140615
"Identifying biochemical phenotypic differences between cryptic species"
[40] Hao,J., Liebeke, M., Deneiro, M., Astle, W., Bundy, JG., Ebbels T. 
Nature Protocols 9,1416–1427
"Bayesian Deconvolution and quantification of Metabolites in Complex 1D NMR Spectra Using BATMAN"

[39] Liebeke, M., Lalk, M.
International Journal of Medical Microbiology 304, pp 222–229
"Staphylococcus aureus metabolic response to changing environmental conditions - a metabolomics perspective"
[38] Bundy, JG., Kille, P., Liebeke, M., Spurgeon, DJ.
Environmental Science & Technology 2014, 48 (2), pp 885–886
"Metallothioneins may not be enough - the role of phytochelatins in invertebrate metal detoxification"
[37] Krismer, B.; Liebeke, M.; Janek, D.; Rautenberg, M.; Hornig, G.; Weidenmaier, C.; Lalk, M.; Peschel, A. 
PloS Pathogens (10(1): e1003862. doi:10.1371/journal.ppat.1003862)
"Nutrient Limitation Governs Staphylococcus aureus Metabolism and Niche Adaptation in the Human Nose."
    Nature Reviews Microbiology - Research Highlight: Adapting to a nasal lifestyle  
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2013

[36] Liebeke, M.*, Garcia-Perez, I.*,Anderson, CJ.*, Lawlor, AJ, Bennett, MH.,Morris, CA., Kille, P., Spurgeon, DJ, Bundy, JG.
PLoS ONE 8(11): e81271
“Earthworms produce phytochelatins in response to arsenic.”

[35] Behrends,V., Bell, T., Liebeke, M., Cordes-Blauert, A., Ashraf, S., Nair, C., Zlosnik, J., Williams, H., Bundy, J.  
Journal of Biological Chemistry, 288 (21):15098–15109
“Metabolite profiling to characterize disease-related bacteria: gluconate excretion by Pseudomonas aeruginosa mutants and clinical isolates from cystic fibrosis patients”

[34] Liebeke, M., Hao, J., Ebbels, T, Bundy, JG. 
Analytical Chemistry 85: 4605−4612
“Combining simple spectral ordering approach with peak fitting for one-dimensional NMR quantitative metabolomics”

[33] Meier, T., Marcos, J., Wodke, AHJ., Liebeke, M., Gutiérrez-Gallego, R., Serrano, L. 
Molecular BioSystems 9, 1743-1755
“Comprehensive metabolome analysis and quantitative integration with proteomics data in Mycoplasma pneumoniae”

[32] Mader, D., Liebeke, M., Winstel, V., Leibig, M., Götz,, F., Lalk M., Peschel, A.
BMC Microbiology 2013, 13(1):7
“Role of N-terminal protein formylation for central metabolic processes in Staphylococcus aureus”

[31] Liebeke, M., Bundy, JG. 
Biochemical and Biophysical Research Communications 430(4), 1306-1311
“Biochemical diversity of betaines in earthworms” pdf

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2012

[30] Geiger, T., Francois, P., Liebeke, M., Frauenholz, M., Goerke, C., Krismer, B., Schrenzel, J., Lalk, M., Wolz, C. (2012)
PloS Pathogens 8(11): e1003016

“The Stringent Response of Staphylococcus aureus and its involvement in surviving phagocytosis through the induction of intracellular PSMs expression.”

[29] Liebeke, M., Bundy, JG. (2012)
Metabolomics 8:819–830
“Tissue disruption and extraction methods for metabolic profiling of an invertebrate sentinel species”

[28] Kleiner, M., Wentrup, C., Lott, C., Teeling, H., Wetzel, S., Young, J., Chang, J., Shah, M., VerBerkmoes, N., Zarzycki, J., Fuchs, G., Markert, S., Hempel, K., Voigt, B., Becher, D., Liebeke, M., Lalk, M., Albrecht, D., Hecker, M., Schweder, T., Dubilier, N. (2012)
Proc Natl Acad Sci USA 109 (19):E1173-82
“Metaproteomics of a gutless marine worm and its symbiotic microbial community reveal unusual pathways for carbon and energy use"

[27] Reiss, S., Pane-Farre, J., Fuchs, S., Francois, P., Liebeke, M., Lalk, M., Schrenzel, J., Wolz, C., Hecker, M., Engelmann, S. (2012) 
Antimicrobial Agents and Chemotherapy 56 (2):787-804
“Global analysis of the Staphylococcus aureus response to mupirocin”

[26] Birkenstock, T.*; Liebeke, M.*; Winstel, V.; Krismer, B.; Gekeler, C.; Niemiec, MJ; Bisswanger, H.; Lalk, M.; Peschel, A. (2012)
Journal of Biological Chemistry 287 (4):2887–95
“Exometabolome analysis identifies pyruvate dehydrogenase as a target for the antibiotic triphenyl-bismuthdichloride in multiresistant bacterial pathogens.”

[25] Liebeke, M., Dorries, K., Meyer, H., Lalk, M. (2012) Methods Mol Biol  815, 377-398
“Metabolome Analysis of Gram-Positive Bacteria such as Staphylococcus aureus by GC-MS and LC-MS” –bookchapter-

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2011

[24] Tredwell, G., Behrend, V., Geier, FA., Liebeke, M., Bundy, JG. (2011)
Analytical Chemistry 15; 83(22): 8683-7
“Between-person comparison of metabolite fitting for NMR-based quantitative metabolomics”

[23] Liang, CG.; Liebeke, M.; Schwarz, R.; Zuhlke, D.; Fuchs, S.; Menschner, L.; Engelmann, S.; Wolz, C.; Jaglitz, S.; Bernhardt, J.; Hecker, M; Lalk, M.; Dandekar, T. (2011)
Proteomics 11, 1915–35
“Staphylococcus aureus physiological growth limitations: Insights from flux calculations built on proteomics and external metabolite data.”

[22] Liebeke, M.*, Dorries, K.*, Zuhlke, D.*, Bernhardt, J; Fuchs, S; Pane-Farre, J; Engelmann, S; Volker, U; Bode, R; Dandekar, T; Lindequist, U; Hecker, M; Lalk, M (2011)
Molecular BioSystems 7, 1241–53
“A metabolomics and proteomics study of the adaptation of Staphylococcus aureus to glucose starvation.”

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2010

[21] Leibig, M., Liebeke, M., Mader, D., Lalk, M., Peschel, A., Gotz, F. (2010)
J Bacteriology 193(4): 952–62
“Pyruvate formate lyase acts as a formate supplier for metabolic processes under anaerobiosis in Staphylococcus aureus”

[20] Wilmes, B., Hartung, A., Lalk, M., Liebeke, M., Schweder, T., Neubauer, P. (2010)
Microbial Cell Factories 9: 72
“Fed-batch process for the psychrotolerant marine bacterium Pseudoalteromonas haloplanktis“

[19] Liebeke, M., Meyer, H., Donat, S., Ohlsen, K., Lalk, M. (2010)
Chemistry and Biology 17: 820–30
“A Metabolomic View of Staphylococcus aureus and Its Ser/Thr Kinase and Phosphatase Deletion Mutants: Involvement in Cell Wall Biosynthesis.”

[18] Thanh, T., Jurgen, B., Bauch, M., Liebeke, M., Lalk, M., Ehrenreich, A., Evers, S., Maurer, KH., Antelmann, H., Ernst, F., Homuth, G., Hecker, M., Schweder, T. (2010)
Appl Microbiol Biotechnol 87:2227–35
“Regulation of acetoin and 2,3-butanediol utilization in Bacillus licheniformis”

[17] Meyer, H.*, Liebeke, M.*, and Lalk, M. (2010). 
Analytical Biochemistry 401:250–9
“A protocol for the investigation of the intracellular Staphylococcus aureus metabolome.”

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2009

[16] Gaupp, R., Schlag, S., Liebeke, M., Lalk, M., and Gotz, F. 
J Bacteriology 192(9): 2385–94
“Advandage of up-regulation of succinate dehydrogenase in Staphylococcus aureus biofilm.”

[15] Pagels, M., Fuchs, S., Pané-Farré, J., Kohler, C., Menschner, L., Hecker, M., McNamarra, P.J., Bauer, M.C., Wachenfeldt, C.v., Liebeke, M., Lalk, M., Sander, G., Eiff, C.v., Proctor, R.A., and Engelmann, S.
Molecular Microbiology 76(5):1142–61
“A redox sensing mechanism by a Rex-family repressor is involved in the regulation of anaerobic gene expression in Staphylococcus aureus.”

[14] Geiger, T., Goerke, C., Fritz, M., Schäfer, T., Ohlsen, K., Liebeke, M., Lalk, M., Wolz, C.  
Infection and Immunity 78(5):1873–83
“Role of the (p)ppGpp synthase RSH, a RelA/SpoT homolog, in stringent response and virulence of Staphylococcus aureus.”

[13] Liebeke, M., Wunder, A., Lalk, M. 
Analytical Biochemistry 401:312–4
“A rapid microwave-assisted derivatization of bacterial metabolome samples for gaschromatography/mass spectrometry analysis.”

[12] Pother, D.C.*, Liebeke, M.*, Hochgrafe, F., Antelmann, H., Becher, D., Lalk, M., Lindequist, U., Borovok, I., Cohen, G., Aharonowitz, Y., and Hecker, M.
J Bacteriology 191(24): 7520–30
“Diamide triggers mainly S-thiolations in the cytoplasmic proteome of Bacillus subtilis and Staphylococcus aureus.”

[11] Michalik, S., Liebeke, M., Zuhlke, D., Lalk, M., Bernhardt, J., Gerth, U., and Hecker, M. Proteomics 9 (19): 4468-77.
“Proteolysis during long-term glucose starvation in Staphylococcus aureus COL.”

[10] Hamberger, J.; Liebeke, M.; Kaiser, M., Bracht, K.; Olszewski, U.; Zeillinger, R.; Hamilton, G.; Braun, D.; Bednarski, PJ.
Anticancer-Drugs, 20: 559-72.
“Characterisation of chemosensitivity and resistance of human cancer cell lines to platinum(II) and platinum(IV) anticancer agents.”

[9] Donat, S., Streker, K., Schirmeister, T., Rakette, S., Stehle, T., Liebeke, M. ; Lalk, M.; Ohlsen, K. 
J Bacteriology 191(13): 4056-69.
“Transcriptome and functional analysis of the eukaryotic-type ser/thr kinase PknB in Staphylococcus aureus.”

[8] Liebeke, M., Brozel, V.S., Hecker, M., and Lalk, M.
Applied Microbiology Biotechnol 83: 161-73
“Chemical characterization of soil extract as growth media for the ecophysiological study of bacteria.”

[7] Nguyen, T.T., Eiamphungporn, W., Mader, U., Liebeke, M., Lalk, M., Hecker, M., Antelmann, H., Helmann, JD 
Molecular Microbiology 71: 876-94
“Genome-wide responses to carbonyl electrophiles in Bacillus subtilis: control of the thiol- dependent formaldehyde dehydrogenase AdhA and cysteine proteinase YraA by the MerR- family regulator YraB (AdhR).”

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2008

[6] Schlag, S., Fuchs, S., Nerz, C., Gaupp, R., Engelmann, S., Liebeke, M., Lalk, M., Hecker, M., Goetz, F.  
J Bacteriology 190: 7847-58.
“Characterization of the oxygen-responsive NreABC regulon of Staphylococcus aureus.”

[5] Kohler, C., von Eiff, C., Liebeke, M., McNamara, P.J., Lalk, M., Proctor, R.A., Hecker, M., Engelmann, S. 
J Bacteriology 190: 6351-64.
“A defect in menadione biosynthesis induces global changes in gene expression in Staphylococcus aureus.”

[4] Liebeke, M.*, Pother, D.C.*, van Duy, N., Albrecht, D., Becher, D., Hochgrafe, F., Lalk, M., Hecker, M., Antelmann, H. 
Molecular Microbiology 69: 1513-29
“Depletion of thiol-containing proteins in response to quinones in Bacillus subtilis.”

[3] Hochgrafe, F., Wolf, C., Fuchs, S., Liebeke, M., Lalk, M., Engelmann, S., and Hecker, M. 
J Bacteriology 190: 4997-5008.
“Nitric oxide stress induces different responses but mediates comparable protein thiol protection in Bacillus subtilis and Staphylococcus aureus.”

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2007

[2] Bracht, K., Liebeke, M., Ritter, C.A., Grunert, R., and Bednarski, P.J. 
Anticancer Drugs 18: 389-404
“Correlations between the activities of 19 standard anticancer agents, antioxidative enzyme activities and the expression of ATP-binding cassette transporters: comparison with the National Cancer Institute data.”

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2006

[1] Saczewski, J., Brzozowski, Z., Saczewski, F., Bednarski, P.J., Liebeke, M., and Gdaniec, M. Bioorganic & Medicinal Chemistry Letters 16: 3663-67.
“Synthesis and in vitro anti-tumor activity of N-{1- (3-thioxo-5,6-dihydroimidazo 2,1-c 1,2,4 thiadiazol-7-ylthio)thio carbonyl -2-imidazolidene}arylsulfonamides.”

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in preparation

[48] Geier, B., Dubilier, N., Liebeke, M.
"A correlative approach for combining multimodal imaging techniques in a 3D scenario"

[47] Geier, B.; Oetjen, J.; Dubillier, N.
, Liebeke, M.
"MALDI-MS imaging combined with fluorescence in situ hybridization, linking host-microbe interactions"

[46] Kleiner, M., Liebeke, M., Wentrup, C, Zarzycki, J., Kiefer, P. Vorholt, J., Dubilier, N.
"Novel metabolic pathway for the massive assimilation of host waste products into carbon storage by the chemolithoautotrophic symbiont of a gutless marine worm"

[45] Kleiner, M., Bergin, C., Lott, C., Häusler, S., Liebeke, M., Wentrup, C., Musat, N., Vagner, T., Kuypers, M.M.M., Dubilier, N., Polerecky, L.
“Single-cell analysis and modelling of autotrophic carbon fixation and carbon transfer in a gutless marine worm symbiosis.”

[44] Liebeke, M.*, Lahive, E.*, Spurgeon, D., Hao, J., Ebbels, T., Svendson, C., Bundy, JG.
"Defining the physiological niche space of an environmental sentinel through metabolic profiling"

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